Tirzepatide
10 mgTitration schedule
Full ramp to 15 mg weeklyApproved-label adult dose-escalation and maintenance context.
| Stage | Weekly amount | U-100 draw |
|---|---|---|
| Weeks 1-4 | 2.5 mg once weekly | 75 units |
| Weeks 5-8 | 5 mg once weekly | 150 units |
| Weeks 9-12 | 7.5 mg once weekly | 225 units |
| Weeks 13-16 | 10 mg once weekly | 300 units |
| Weeks 17-20 | 12.5 mg once weekly | 375 units |
| Week 21+ | 15 mg once weekly - maintenance | 450 units |
A calculated dose above 100 units exceeds one 100-unit U-100 syringe at this concentration. Use an appropriate multi-draw plan and verify the full dose.
A dose above 10 mg requires more than one selected 10 mg vial. A 15 mg dose cannot come from a single 10 mg vial.
Escalation / hold
Escalation is not automatic. Hold the current dose longer when tolerability requires it. The 2.5 mg dose is for initiation; 7.5 mg and 12.5 mg are escalation steps; 5 mg, 10 mg, and 15 mg are maintenance targets.