PPeptide Bible

Peptide entry

MOTS-c

Research peptidePeptide
Weight LossMitochondrial

Quick facts

Category
Weight Loss, Mitochondrial
Primary goal
Fat Loss (Advanced), Longevity / Mitochondrial Support
Dose pattern
Weekly
Treatment style
Fixed-dose or range
Status
Research peptide
Vial formats
40 mg; 10 mg

Evidence / context

Evidence: Limited. Mitochondrial and metabolic-support use is best judged by repeatable response.

Available vial formats

MOTS-c

40 mg
Mix 3.0 mLConcentration 13.33 mg/mL

Dosing

  • Conservative 2.5 mg per injection, 2-3 times weekly (19 units per injection)
  • Standard 5 mg per injection, 2-3 times weekly (38 units per injection)
  • Aggressive 5 mg per injection once daily short-term only (38 units per injection), or 10 mg per injection 1-2 times weekly only if clearly tolerated (75 units per injection)
Cycle length2-6 weeks; keep aggressive blocks short and reassess.
TimingMorning or pre-workout.Avoid late evening if it causes stimulation or sleep disruption.

MOTS-c

10 mg
Mix 2.0 mLConcentration 5 mg/mL

Dosing

  • Conservative 2.5 mg per injection, 2-3 times weekly (50 units per injection)
  • Standard 5 mg per injection, 2-3 times weekly (100 units per injection)
  • Aggressive 5 mg per injection once daily short-term only (100 units per injection), or 10 mg per injection 1-2 times weekly only if clearly tolerated (200 units per injection)
Cycle length2-6 weeks; keep aggressive blocks short and reassess.
TimingMorning or pre-workout.Avoid late evening if it causes stimulation or sleep disruption.

Reconstitution

  1. Swab vial tops with alcohol
  2. For 40 mg vial, add 3.0 mL bacteriostatic water slowly
  3. For 10 mg vial, add 2.0 mL bacteriostatic water slowly
  4. Inject slowly down vial wall (don't blast powder)
  5. Gently swirl - do not shake
  6. Rest 5-10 min to dissolve
  7. Refrigerate 2-8 C

Support / expected effects

Side effects / tolerability

Practical tips

Storage

Refrigerated: ~45-60 days.

Notes / compatibility

Compatibility

Rule: only mix water-based peptides sharing the same diluent and timing intent. If unsure, keep separate.

FAQ

What is MOTS-c explored for?

Insulin sensitivity/fuel partitioning support. Often reported: endurance/recovery. Fat oxidation/metabolic flexibility support.

How is MOTS-c reconstituted?

1) Swab vial tops with alcohol 2) For 40 mg vial, add 3.0 mL bacteriostatic water slowly 3) For 10 mg vial, add 2.0 mL bacteriostatic water slowly 4) Inject slowly down vial wall (don't blast powder) 5) Gently swirl - do not shake 6) Rest 5-10 min to dissolve 7) Refrigerate 2-8 C

What is a typical cycle length for MOTS-c?

2-6 weeks; keep aggressive blocks short and reassess.

How are doses measured in syringe units here?

Units mean U-100 insulin-syringe gradations (1 mL = 100 units), not International Units. Use the calculator only when the vial concentration and injection volume are known.

Related references

Related peptides

5-Amino-1MQAOD-9604CagrilintideL-CarnitineNAD+RetatrutideSemaglutideSS-31

Categories

Weight LossMitochondrial

Goal guides

Fat Loss (Advanced)Longevity / Mitochondrial Support

Useful guides and tools

Reconstitution BasicsPeptide Cycle GuideU-100 Syringe Units ExplainedPeptide calculator
Calculate the exact draw for MOTS-cPreloads the relevant vial format or fixed-ratio blend cycle.
Open calculator