PPeptide Bible

Peptide entry

Semaglutide

Approved drugPeptide
Weight Loss

Also known as: Ozempic molecule, Wegovy molecule

Quick facts

Category
Weight Loss
Primary goal
Fat Loss (Beginner)
Dose pattern
Weekly, titrated
Treatment style
Titrated
Status
Approved drug
Vial formats
10 mg

Evidence / context

Evidence: Strong approved-drug evidence exists for the molecule; formulation and indication matter.

Available vial formats

Semaglutide

10 mg
Mix 3.0 mLConcentration 3.333 mg/mL

Titration schedule

Full ramp to 7.2 mg weekly - optional higher adult maintenance target

Approved-label adult weight-management dose-escalation context; the optional 7.2 mg adult target is shown separately.

StageWeekly amountU-100 draw
Weeks 1-40.25 mg once weekly7.5 units
Weeks 5-80.5 mg once weekly15 units
Weeks 9-121 mg once weekly30 units
Weeks 13-161.7 mg once weekly51 units
Weeks 17-202.4 mg once weekly (at least 4 weeks)72 units
Week 21+7.2 mg once weekly - maintenance216 units

Not an automatic next step; only after at least four weeks tolerating 2.4 mg. Not for pediatric schedules.

A calculated dose above 100 units exceeds one 100-unit U-100 syringe at this concentration. Use an appropriate multi-draw plan and verify the full dose.

Escalation / hold

Escalation is not automatic. Hold the current dose longer when tolerability requires it. The optional 7.2 mg adult target may only follow at least four weeks tolerating 2.4 mg and does not apply to pediatric schedules.

Reconstitution

  1. Swab vial tops with alcohol
  2. Draw 3.0 mL bacteriostatic water
  3. Inject slowly down vial wall (don't blast powder)
  4. Gently swirl - do not shake
  5. Rest 5-10 min to dissolve
  6. Refrigerate 2-8 C

Treatment duration

Continue the selected once-weekly maintenance target for the remaining planning period rather than treating it as an on/off peptide cycle.

Timing

Use the same day each week.

Support / expected effects

Side effects / tolerability

Practical tips

Storage

Refrigerated: ~45-60 days.

Notes / compatibility

Semaglutide Screening Notes

Screening should follow clinician guidance and the approved-drug context for GLP-1 medicines.

  • Personal or family history of medullary thyroid carcinoma (MTC) or MEN2: clinician review before use.
  • Prior pancreatitis: clinician review is needed.
  • Significant gallbladder disease or severe gallbladder events: clinician review is needed.
  • Severe GI disease, severe gastroparesis, or major motility issues: clinician review is needed.
  • Pregnancy, trying to conceive, or breastfeeding: avoid unless directed by a qualified clinician.
  • Diabetes medications, insulin, sulfonylureas, or hypoglycemia risk: clinician review because blood glucose can change.
  • Vomiting, diarrhea, or poor intake can raise dehydration risk; pause escalation and address fluids/electrolytes if this occurs.

Compatibility

Rule: only mix water-based peptides sharing the same diluent and timing intent. If unsure, keep separate.

FAQ

What titration schedule is shown for Semaglutide?

Each vial card shows the same 7.2 mg weekly - optional higher adult maintenance target. Approved-label adult weight-management dose-escalation context; the optional 7.2 mg adult target is shown separately.

How does Semaglutide titration work?

Start at 0.25 mg once weekly and follow the stages shown in the vial card. Escalation is not automatic. Hold the current dose longer when tolerability requires it. The optional 7.2 mg adult target may only follow at least four weeks tolerating 2.4 mg and does not apply to pediatric schedules.

What is the treatment-duration context for Semaglutide?

Continue the selected once-weekly maintenance target for the remaining planning period rather than treating it as an on/off peptide cycle.

How are doses measured in syringe units here?

Units mean U-100 insulin-syringe gradations (1 mL = 100 units), not International Units. Use the conversion table for the selected vial format and confirm syringe and vial capacity.

Related references

Related peptides

RetatrutideTirzepatideCagrilintide5-Amino-1MQAOD-9604L-CarnitineMOTS-cTesamorelin

Categories

Weight Loss

Goal guides

Fat Loss (Beginner)

Useful guides and tools

Reconstitution BasicsPeptide Cycle GuideU-100 Syringe Units ExplainedPeptide calculator
Calculate the exact draw for SemaglutidePreloads the relevant vial format or fixed-ratio blend cycle.
Open calculator