PPeptide Bible

Peptide entry

Retatrutide

InvestigationalPeptide
Weight Loss

Also known as: Triple agonist

Quick facts

Category
Weight Loss
Primary goal
Fat Loss (Advanced)
Dose pattern
Weekly, titrated
Treatment style
Titrated
Status
Investigational
Vial formats
10 mg; 20 mg

Evidence / context

Evidence: Emerging. Use context is formulation-dependent.

Available vial formats

Retatrutide

10 mg
Mix 2.5 mLConcentration 4 mg/mL

Titration schedule

Full ramp to 12 mg weekly

Investigational trial schedule - not an approved prescribing schedule.

StageWeekly amountU-100 draw
Weeks 1-42 mg once weekly50 units
Weeks 5-84 mg once weekly100 units
Weeks 9-126 mg once weekly150 units
Weeks 13-169 mg once weekly225 units
Week 17+12 mg once weekly - maintenance300 units

A calculated dose above 100 units exceeds one 100-unit U-100 syringe at this concentration. Use an appropriate multi-draw plan and verify the full dose.

Treatment duration

Retatrutide is studied as continuing once-weekly treatment after titration, not as a short on/off cycle. The selected target dose continues for the remaining planning period after escalation.

Escalation / hold

Escalation is not automatic. Hold the current dose longer when tolerability requires it.

Retatrutide

20 mg
Mix 2.5 mLConcentration 8 mg/mL

Titration schedule

Full ramp to 12 mg weekly

Investigational trial schedule - not an approved prescribing schedule.

StageWeekly amountU-100 draw
Weeks 1-42 mg once weekly25 units
Weeks 5-84 mg once weekly50 units
Weeks 9-126 mg once weekly75 units
Weeks 13-169 mg once weekly112.5 units
Week 17+12 mg once weekly - maintenance150 units

A calculated dose above 100 units exceeds one 100-unit U-100 syringe at this concentration. Use an appropriate multi-draw plan and verify the full dose.

Treatment duration

Retatrutide is studied as continuing once-weekly treatment after titration, not as a short on/off cycle. The selected target dose continues for the remaining planning period after escalation.

Escalation / hold

Escalation is not automatic. Hold the current dose longer when tolerability requires it.

Reconstitution

  1. Swab vial tops with alcohol
  2. Draw 2.5 mL bacteriostatic water
  3. Inject slowly down vial wall (don't blast powder)
  4. Gently swirl - do not shake
  5. Rest 5-10 min to dissolve
  6. Refrigerate 2-8 C

Timing

Evening can be useful if nausea is easier to manage overnight.

Support / expected effects

Side effects / tolerability

Practical tips

Storage

Refrigerated: ~45-60 days.

Notes / compatibility

Compatibility

Rule: only mix water-based peptides sharing the same diluent and timing intent. If unsure, keep separate.

FAQ

What titration schedule is shown for Retatrutide?

Each vial card shows the same 12 mg weekly. Investigational trial schedule - not an approved prescribing schedule.

How does Retatrutide titration work?

Start at 2 mg once weekly and follow the stages shown in the vial card. Escalation is not automatic. Hold the current dose longer when tolerability requires it.

What is the treatment-duration context for Retatrutide?

Retatrutide is studied as continuing once-weekly treatment after titration, not as a short on/off cycle. The selected target dose continues for the remaining planning period after escalation.

How are doses measured in syringe units here?

Units mean U-100 insulin-syringe gradations (1 mL = 100 units), not International Units. Use the conversion table for the selected vial format and confirm syringe and vial capacity.

Related references

Related peptides

SemaglutideTirzepatideCagrilintide5-Amino-1MQAOD-9604L-CarnitineMOTS-cTesamorelin

Categories

Weight Loss

Goal guides

Fat Loss (Advanced)

Useful guides and tools

Reconstitution BasicsPeptide Cycle GuideU-100 Syringe Units ExplainedPeptide calculator
Calculate the exact draw for RetatrutidePreloads the relevant vial format or fixed-ratio blend cycle.
Open calculator